Although Leukotriene B4 is a powerful mediator in inflammation, especially in neutrophil chemotaxis and activation, it is not specifically associated with autoimmune disorders like lupus nephritis.

Histamine is not the major player in immune complex mediated damage, although it plays a critical role in immediate type hypersensitivity reactions.

TNF-alpha is involved in systemic inflammation, and although it might rise in many inflammatory conditions including autoimmune diseases, it is not directly implicated in resulting kidney damage in this context. It is crucial in the formation of granulomas, especially in diseases like tuberculosis.

IL-1 is an important mediator in inflammation and might contribute to the systemic symptoms in lupus patients, but it is not directly involved in the pathogenesis of lupus nephritis.