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How will you do?

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DIFFICULTY: HARD
A 59-year-old man presents to your clinic for a regular checkup. During the physical examination, you notice he has a bluish discoloration on his lips and fingertips. He mentions that he has been feeling a bit fatigued recently. Understanding the physiological changes in the body, which of the following would you consider to be the most probable cause of his condition?
A
B
C
D
E