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Yeah, for your life. So, hello everyone. Uh Thank you very much for joining us tonight uh for our systematic review and meta analysis webinar event. It's a joint event between scrubs and the student healthcare audit society and we appreciate you coming along. Um So you're in for a really good session tonight. Um Tonight, we have uh two principal investigators for senior researchers and the welcome with in Institute of Experimental Medicine here at Queens. They have thankfully uh given up their time to give us a bit of teaching. So they are Professor Bruna Blackwood and Professor Brony Connelly. Um Professor Blackwood's research interest are in improving clinical trial contract while also undertaking critical care uh clinical trials, they focus on mechanical ventilation. Um And then Professor Connolly's work investigates acute respiratory and uh rehabilitation physiotherapy and critical illness alongside critical clinical trial methodology concerning complex interventions for rehabilitation. So, um yeah, we have uh experts experts tonight. Um So I will hand a word to Professor Blackwood and Professor Connolly. So thank you. Thanks James. That's a lovely introduction and it's wonderful to be part of your um training session this evening. So, thank you for the invitation. Uh We're both really looking forward to delivering this session for you and any questions or queries, comments that you have, you can add into the, into that function online and we'll have some time at the end that we can answer any of those questions uh with you. And the way we're going to um run the session is that um II, we'll introduce ourselves in, but I'll, I'll pick up the first part and then Brina and I are gonna swap over and Broner will lead the second part of the session. So you might just see a swapping over chairs so that we can more easily access the camera um and, and deliver those parts of the session. Um So James said, uh my name's Bronwyn Connolly, I'm a physiotherapist by professional background. Um And my interests are in acute respiratory failure and rehabilitation um for patients both within the intensive care unit and as they recover afterwards, fair enough. Hello everyone. I'm Verona Blackwood and my discipline is nursing. Um And my research is, is about weaning from mechanical ventilation and you'll hear a wee bit more about some of that work this evening as we're talking about systematic reviews. Um I'm also um uh a Cochrane editor in the Cochrane Emergency and Critical Care Group and I'm also the Northern Ireland lead for Evidence Synthesis. Ireland, which is linked with Cochrane, Ireland. So I'll hand over to you. You're gonna start the session from them shortly. Thank you. Right. So the first part of what we will cover this evening is around systematic reviews. Um Let me just put that into screen you there. So hopefully everybody can now see those slides in full. Um So let's think about why we're doing a systematic review and, and how that fits into the broader um the broader remit of literature review. So you might have heard different terms about reviews, literature reviews, systematic reviews, meta analysis. Um Sorry, let me just um switch these around all. Good. Thank you. Um And so let's think a little bit about where systematic reviews fit into the whole range of uh literature reviews that that can be done. So a broad literature review may cover, let's take this topic, for example, using tea tree oil for preventing MRSA colonization in critically ill patients. If we were to do AAA broad literature review around this topic, we might be looking at covering um content such as the etiology and the the epidemiology of M RSA. What might be the risk factors which patients might be most at risk? What particular interventions are there already in the literature for preventing colonization and what potential new interventions are there such as tea tree oil? And that would give the reader a really lovely overview of the topic. They would understand the background, what the current evidence is, what potential new treatments there are. Uh and perhaps where the field is going, it's quite broad and it covers a range of content for the reader. A systematic review is really one part of the broad lit uh broad literature review field. This answers a much more specific question about this topic and it answers primarily a question about the effectiveness of treatments and what we'll cover this evening when we're talking about systematic reviews is primarily systematic reviews that look at the effectiveness of an intervention. So in this instance, we would be asking a very specific question to answer through the systematic review process. And so that would be is tea tree oil body wash effective at preventing colonization with M RSA in critically ill adult patients. And as we'll talk about in a few slides time, keep this question in mind because within this question, there are all of the core components of a population and intervention and what we think the outcome might be and we'll, we'll talk through that a little bit more as we progress through the slides. But this gives you a sense of um where a systematic review would fit in the, in the broader field of literature reviews. And as I've just uh picked up again here, you can see that within our systematic review question, we would be describing the condition, the intervention, what we think it might be doing in terms of, of mechanism of working a and why it's important to do as well. Now Broner mentioned that she was a content editor within the Cochrane emergency and critical care sector. The Cochrane Library is really the the gold standard repository of systematic reviews of effectiveness of different health care interventions across a whole range of different um disciplines, different healthcare settings, different specialties, anything that you want to to look up in terms of really high quality systematic review evidence or the effectiveness of an intervention. This is the place to go and the value of the Cochrane Library is that it has it contains all of these uh systematic reviews and meta analysis. But it also ensures that any systematic review that is done under the Cochrane banner is done according to really high rigorous methods. So you know exactly uh what you should expect to see from any Cochrane systematic review. That's not to say that if you come across a systematic review elsewhere that it's not rigorously done many systematic reviews that might get published in other journals will say that they're following Cochrane methodology. But the the reassuring process or the reassuring aspect here is that if you go to the Cochrane website, which you can do er through the QR code, that's that's linked here. It really is that repository of of kind of high quality gold standard systematic reviews around the effectiveness of of all interventions and how they link into health care and health policy. So you can see here the types of Cochrane review that they house within their library intervention reviews and that's particularly what we'll be focusing on this evening, but also systematic reviews that look at the accuracy of diagnostic testing, perhaps qualitative evidence synthesis, er methodology reviews, overviews of reviews which are a particular um er er research method around doing systematic reviews where they might multiple reviews in an area. Um and then rapid reviews and we saw a lot of that during the COVID pandemic, for example, Cochrane were leading the way in terms of rapidly producing evidence synthesis uh to guide practice um during the pandemic. So that's often the the the reason why we have rapid reviews. So we strongly suggest uh if you're interested in this area, click onto the QR code and explore the Cochrane Library uh and get to know the the the resources that they have available. So what we're gonna focus on um this evening in particular is why systematic reviews are beneficial for you um that you'll get an understanding of how you, you can use those in your practice, how you come across them in, in your own studies and in in your clinical work to come the steps in a systematic review that make it robust. Why is this a really reliable source of um of of a publication? Why is this gonna be a valuable resource to you? If you see a systematic review that tells you whether something's effective or not, why would that be a reliable source uh for you to conclude and also how these steps lead to accurately interpreting the evidence, to guide your practice. So we're all here to improve the outcomes for our patients and to deliver the best health care possible. And we need to do that through delivering evidence based health care. Uh So we need to do that. We need to understand where is the strong evidence for a treatment? Um Where is there an evidence gap? So we understand if we're delivering a treatment that it may not be completely informed and that there may be research to come and that helps us to be informed and it helps us to allow our patients to be informed about the decisions they're making around their health care. So why again do we need systematic reviews in terms of how do they help the the evidence at the moment? So, I mean, I think we're all familiar with this a little bit. We need reliable information and quite frankly, there's too much information out there. You know, you can click on Google and come across 100s and 100s of studies sometimes in a particular area and it becomes very difficult to keep up to date in a method that is efficient and effective and and allows you to feel confident with the evidence. So you can see