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Down’s Syndrome (Trisomy 21) Features ↑ Nuchal Translucency Muscle Hypotonia (floppy) Brushfield spots (on the iris) Single Palmar Crease (transverse) Low-set ears Upslanting palpebral fissures (the opening between the eyelids) Epicanthic folds (eyelid) Flattened facial features Bilateral, Curved 5th finger (clinodactyly) Sandal Gap Deformity (big toes widely spaced) Developmental Delay (↓ IQ) Large Tongue (in comparison to head size) OSCEazy PreClinEazy