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European University Of Cyprus Red light therapy and it’s role in skin anti- aging Charilaos Spanoudis STUDY LIMITATIONS INTRODUCTION RESULTS Red light therapy has been explored as a non- So, to some up the results from the scientific literature on • Several studies had small invasive method to combat facial wrinkles, a natural red light therapy for skin rejuvenation: sample sizes. consequence of aging and UV exposure. By potentially boosting cellular ATP production, red light Positive Findings: may stimulate skin rejuvenation. • Several studies indicate that red light therapy can • Many studies primarily Studies, including RCTs, demonstrate improvements improve skin complexion, reduce wrinkle severity included female participants, in wrinkles, skin complexion, and collagen density and density, and increase collagen density. using red LEDs. Comparisons of red and amber limiting generalizability to LEDs show both enhance quality of life, with red males. showing a slight advantage in wrinkle reduction. • Red light therapy has shown promise in treating facial wrinkling in middle-aged women. • Some studies lacked control • Both red and amber LED light therapies improved groups or had other quality of life with minimal side effects. methodological limitations. Optimal Treatment Parameters: • Studies suggest that 2-3 weekly sessions of red • The effects of participants' skincare routines were not light therapy are more effective than daily applications. always clear. Figure1: Light penetration level according to its wavelength [5] • Lower radiant exposure (3.8 J/cm2) yields better • There is a lack of outcomes than higher radiant exposure (66–1266 J/cm2). standardized protocols for red light therapy due to the • Lower irradiance (6.4 mW/cm2)is more efficient variability in parameters. METHODS . than higher irradiance (50–105 mW/cm2). • Low-level laser therapy devices: Devices that emit red or near- infrared light at low power levels. REFERENCE • Polychromatic-spectrum light therapy: Therapy that uses a wide range of light wavelengths. 1.Swift A, Liew S, Weinkle S,Garcia JK, Silberberg MB. TheFacial Aging ProcessFrom the “Inside Out.” Aesthetic SurgeryJournal [Internet].2020 • Red LED light masks: Masks that Dec 16;41(10). emit red light using light-emitting 2.Pinar Avci, GuptaA, Magesh Sadasivam, Vecchio D, Pam Z, PamN, et al. Low-level laser (light) diodes (LEDs). Figure3: Patient photography examples. (A) 64-year-old woman, therapy (LLLT) in skin: stimulating, healing, energizing light technology (ELT). (B) 41-year-old woman, redlight restoring.Seminars in cutaneous medicine and technology (RLT).[4] surgery[Internet].2013 Mar;32(1):41. 3.Nam CH, Park BC, Kim MH, Choi EH, Hong SP. The Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for TreatingWrinkles. KEY MECHANISMS CONCLUSION Dermatologic Surgery:Official Publication for American Society for Dermatologic Surgery[et Al] Red light and light near it’s spectrum can [Internet].2017 Mar 1;43(3):371–80. penetrate the skin barrier and stimulate the In conclusion, red light therapy represents a promising, 4.Wunsch A, Matuschka K. A controlled trial to mitochondria of our body leading to a cascade non-invasive intervention with exciting potential for the determinethe efficacy of redand near-infrared of different chain reactions. future of dermatology, particularly in addressing the light treatmentin patient satisfaction, reduction challenges of skin aging. The current body of research, of fine lines, wrinkles, skin roughness, and while demonstrating encouraging results in areas such as intradermal collagen density increase. wrinkle reduction, improved skin complexion, and Photomedicine and Laser Surgery[Internet].2014 increased collagen density, also reveals that the Feb 1;32(2):93–100. technology requires further refinement before widespread 5.Virginie Couturaud, Marie Le Fur,Pelletier M, Granotier F.Reverse skin aging signs by redlight clinical recommendation. Key limitations, including small photobiomodulation. Skin Research and sample sizes, demographic biases, and a lack of Technology. 2023 Jun 30;29(7). standardized treatment protocols, highlight the need for 6.Lidiane Rocha Mota, Duarte S,Thais Rodrigues more rigorous and comprehensive studies. Specifically, Galache, Maria K, Orlando Chiarelli Neto, Lara future research should aim to: Jansiski Motta, et al. Photobiomodulation Reduces Include larger and more diverse patient populations, with Periocular Wrinkle Volume by 30%: A Randomized greater representation of males and older individuals. Controlled Trial.2023 Feb 1;41(2):48–56. Employ robust study designs with appropriate control groups and longer follow-up periods. Investigate the optimal parameters for red light therapy, including wavelength, dosage, and treatment frequency, to establish evidence-based guidelines. By addressing these limitations, future studies will help to Figure1: Mechanism of action of LLLT. [2] solidify the role of red light therapy in dermatological practice and pave the way for its effective integration into our arsenal of anti-aging treatments.