Effects of Chios Mastiha essential oil (CMO) on glucose levels of patients with diabetes
Summary
This on-demand teaching session by the European University of Cyprus presents the potential for Chios Mastiha essential oil (CMO) to regulate glucose metabolism and improve insulin sensitivity among diabetic patients. This all-natural product, derived from the resin of the mastic tree, presents numerous therapeutic benefits including antioxidant, anti-inflammatory and cholesterol-lowering effects. The session features a review of studies conducted on CMO's potential benefits for diabetes and a proposal for a future study to further understand CMO's influence on glucose levels. This insightful session is valuable to medical professionals seeking potential new treatments for diabetes, promising a deeper understanding of CMO's potential role in managing diabetes in young patients.
Learning objectives
- Understand the potential medicinal properties of Chios Mastiha essential oil (CMO), including its possible influence on glucose metabolism and insulin sensitivity.
- Analyze the chemical composition of Chios Mastiha essential oil and its impact on human health, specifically in relation to diabetes.
- Evaluate current research literature on the use of CMO for influencing glucose levels in patients with diabetes and identify the gaps in research.
- Develop a comprehensive understanding of the proposed design for a prospective, placebo-controlled study aimed at assessing the impact of CMO on glucose levels in patients with diabetes.
- Critically appraise the safety, efficacy and potential therapeutic application of CMO for managing diabetes, especially in youth. Compare these insights with traditional treatment approaches for diabetes.
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Effects of Chios Mastiha essential oil (CMO) on glucose levels of patients with diabetes European University of Cyprus Aikaterina Bougdanou 01. Abstract: Chios Mastiha essential oil (CMO) is a 03. Methods: Recent studies have investigated its potential role in natural product extracted from the resin of mastiha, with antioxidant, anti-microbial, anti-ulcer, anti- regulating glucose metabolism and insulin sensitivity, suggesting possible benefits for individuals with diabetes. Prospective placebo-controlled neoplastic, cholesterol-lowering capabilities and may studies can also be designed to further study the effect of CMO capsules have antidiabetic effects. Initial studies have suggested that CMO may possibly influence glucose on young patients with diabetes. Volunteers who will participate in the study will be 2:1 ratio of receiving CMO capsules (200 mg mastiha- metabolism and insulin sensitivity in human. This study reviews CMO's potential mechanisms and oil/capsule) and placebo for 8 weeks respectively. proposes the design of a prospective randomized, placebo-controlled study to assess CMO's impact on glucose levels in patients with diabetes. 02. Introduction: Chios Mastic Gum (CMG) is a natural resin, harvested from the branches of the Chios mastic tree, known as Pistacia lentiscus. It is produced in the southern part of Chios, an island located in the Northern Aegean Sea. Mastic is used in many industries and finds its application in both 04. Action Mechanism: Chios Mastic Gum (CMG) has been collected and consumed for medicine and agriculture. (CMG) has extreme chemical complexity, being composed of more than 2500 years and is known for its therapeutic properties. It contains bioactive approximately 120 different compounds. compounds such as essential oils, flavoroids, and phenolic acids, which may contribute to its therapeutic effects. Such compounds have been shown to possess antioxidant properties, reducing oxidative stress, a key factor in the pathogenesis of diabetes (Papadopoulou et al., 2020, Kartalis et al, 2024). Additionally, mastic has demonstrated anti-inflammatory effects, which may help mitigate the chronic inflammation associated with insulin resistance. It exhibits promising properties that may contribute to the regulation and treatment of diabetes. While initial studies in adults are encouraging, there is a critical need for youth-specific research to fully understand its potential benefits and establish evidence-based guidelines for its use in youth diabetes management and the efficacy and safety of CMO in reduction of glucose levels. 05. Clinical evidence: prospective, randomized, placebo- controlled pilot study involving healthy volunteers assessed the effects of Chios mastic gum on cholesterol and glucose levels. The results indicated that mastic supplementation led to significant reductions in blood glucose levels and improvements in lipid profiles (Papadopoulou et al., 2020). In future endeavors it would be beneficial for the study to be done on young participants. After 8 weeks of CMO administration, in the CMO group glucose levels will be compared to their baseline values. . 06. Conclusion: The MASTIHA-OIL study will, thus, complete recent studies. While early studies on adults are promising, the study aims to explore its effects specifically in youth diabetes, potentially offering a natural and References effective treatment option. Kartalis, A., Afendoulis, D., Didagelos, M., Ampeliotis, M., Moutafi, M., Voutas, P., ... & Vlachopoulos, C. (2024). Effects of Chios Mastiha essential oil on cholesterol levels of healthy volunteers: A prospective, randomized, placebo- controlled study (MASTIHA-OIL). Hellenic Journal of Cardiology, 77, 63-69. Papadopoulou, A., Kourkoutas, Y., & Koutinas, A. A. (2020). Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS- MASTIHA). European Journal of Clinical Pharmacology, 22(10), 1307–1313. https://doi.org/10.1007/s00228-020- 02947-0