Rethinking Pulmonary Arterial Hypertension: Targeting the Pathways

Learning objectives

  1. Describe the major pathophysiological pathways underlying PAH and how they inform therapeutic targets.
  2. Apply current international guideline recommendations to ensure evidence-based use of approved PAH therapies.
  3. Differentiate between monotherapy, dual therapy, and triple therapy approaches, highlighting their appropriate use in clinical practice.
  4. Determine when and how to escalate therapy in patients with PAH, using risk stratification and clinical response to guide treatment intensification.
  5. Develop personalized treatment plans that integrate guideline-directed therapy, pathway-based rationale, and patient-specific factors to optimize outcomes.
Specialities: Respiratory
Estimated time: 15 minutes
Credit types: AMA

This program is supported by an independent education grant from MSD. This online education program is designed solely for healthcare professionals in the USA. The content is not available for HCPs in any other country.

Who Should Participate?

This program is for U.S. healthcare professionals involved in PAH care, including:

  • Pulmonologists
  • Cardiologists
  • Internal Medicine Physicians
  • Nurse Practitioners & Physician Assistants
  • Pharmacists
  • Nurses and other HCPs involved in the management of PAH

Continuing Education Information

This continuing education activity will be provided by AffinityCE and MedAll. This activity will provide continuing education credit for physicians. A statement of participation is available to other attendees.

Disclosures
Below is a listing of all individuals who are involved in the planning and implementation of this accredited continuing education activity. All relevant financial relationships listed for these individuals have been mitigated.​

Kelly Chin, MD has disclosed financial interests or relationships within the past 24 months with the following ineligible companies: Advisory Board/Steering or Adjudication Committee for Gossamer Bio, Inhibikase, Janssen, Merck, United Therapeutics. Research Support (for institution) from Gossamer Bio, Janssen, Merck, Novartis, Pulmovant and United Therapeutics. These disclosures are provided in accordance with ACCME standards to ensure transparency and uphold the integrity of continuing education. Dr. Chin does not intend to reference any unlabeled or unapproved uses of products during the presentation.

Sudarshan Rajagopal, MD, PhD has disclosed financial interests or relationships within the past 24 months with the following ineligible companies: Consultant for Altavant, GossamerBio, Insmed, Janssen, Liquidia, Merck, Pahr Therapeutics, United Therapeutics. Research Support from American Heart Association, Janssen, Merck, NIH, United Therapeutics. These disclosures are provided in accordance with ACCME standards to ensure transparency and uphold the integrity of continuing education. Dr. Rajagopal does not intend to reference any unlabeled or unapproved uses of products during the presentation.

These disclosures are made in accordance with ACCME standards to ensure transparency and objectivity in continuing education.

AffinityCE/MedAll staff and the planners and reviewers of this educational activity have no relevant financial or non-financial interests to disclose.​

Mitigation of Relevant Financial Relationships
AffinityCE adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible companies. Relevant financial relationships were mitigated by the peer review of content by non-conflicted reviewers prior to the commencement of the program.

Activity Accreditation for Health Professions

Physicians
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AffinityCE and MedAll. AffinityCE is accredited by the ACCME to provide continuing medical education for physicians.

AffinityCE designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Professionals
All other health care professionals completing this continuing education activity will be issued a statement of participation indicating the number of hours of continuing education credit. This may be used for professional education CE credit. Please consult your accrediting organization or licensing board for their acceptance of this CE activity.

System Requirements

Mobile device (e.g., large-format smart phone; laptop or tablet computer) or desktop computer with a video display of at least 1024 × 768 pixels at 24-bit color depth, capable of connecting to the Internet at broadband or faster speeds, with a current version Internet browser and popular document viewing software (e.g., Microsoft Office, PDF viewer, image viewer) installed. Support for streaming or downloadable audio-visual materials (e.g., streaming MP4, MP3 audio) in hardware and software may be required to view, review, or participate in portions of the program.

Unapproved and/or off-label use disclosure

AffinityCE/MedAll requires CE faculty to disclose to the participants:

  • When products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not US Food and Drug Administration [FDA] approved); and
  • Any limitations on the information presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion.

CME Inquiries

For all CME policy-related inquiries, please contact us at ce@affinityced.com.

Participation Costs

There is no cost to participate in this program.

This continuing education activity is active starting March 28th 2026 and will expire on June 28th 2027.

Estimated time to complete this activity: 15 minutes.

Content correct at the time of publication.